Dilated cardiomyopathies

Dilated cardiomyopathies demonstrate considerable
heterogeneity. Autosomal dominant inheritance may account
for about 25% of cases. Mutations in the cardiac alpha actin
gene have been found in some autosomal dominant families
and an X-linked form (Barth syndrome) is associated with
skeletal myopathy, neutropenia and abnormal mitochondria
due to mutations in the X-linked taffazin gene.
Dystrophinopathy, caused by mutations in the X-linked gene
causing Duchenne and Becker muscular dystrophies can
sometimes present as isolated cardiomyopathy in the absence of
skeletal muscle involvement.