Clinical features of Marfan syndrome

Clinical features of Marfan syndrome evolve with age and
children at risk should be monitored until growth is completed.
More frequent assessment may be needed during the pubertal
growth spurt. Neonatal Marfan syndrome represents a
particularly severe form of the condition presenting in the
newborn period. Early death from cardiac insufficiency is
common. Most cases are due to new mutations, which are
clustered in the same region of the FBN1 gene. Adults with
Marfan syndrome need to be monitored annually with
echocardiography. Pregnancy in women with Marfan syndrome
should be regarded as high risk and carefully monitored by
obstetricians and cardiologists with expertise in management of
the condition.